Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress
نویسندگان
چکیده
منابع مشابه
Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress
Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding the identification of potential therapy. Using an integrative approach at the isolated organ, cellular and molecular levels, we tested the hypothesis that oxidative stress ...
متن کاملPrenatal hypoxia, habituation memory and oxidative stress
Hypoxia-ischemia (HI) is characterized by a reduced supply of oxygen during pregnancy, which leads to both central nervous system and peripheral injuries in the foetus, resulting in impairment in its development. The purpose of this study was to investigate behavioural changes and systemic oxidative stress in adult animals that have been affected by HI during pregnancy. HI was induced by the oc...
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Reactive oxygen species (ROS) include a wide variety of molecules and free radicals derived from molecular oxygen. O2 being highly electrophilic can be reduced by one electron at a time producing relatively stable intermediates, such as superoxide anion (O2 ̄), precursor of most ROS and a relevant mediator in many biological reactions. Dismutation of O2 ̄ produces hydrogen peroxide (H2O2), whic...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0031017